for the dudes outside, make them drive straight at you, but run begind a tree. for me, they ran into the tree and i could rip on the driver and the others without the turret guy shooting me. For Carlito, get the bike in the out door store and swirve out of the way of the snipes. then when ur close, slash him up with any sword/melee weapon available. I used the clowns chainsaws.
